Associação entre cognição e fator de crescimento semelhante à insulina I: revisão integrativa
Association between cognition and insulin-like growth factor I: an integrative review
Asociación entre cognición y factor de crecimiento similar a la insulina I: revisión integrativa
Resumo (pt)
Este estudo teve como objetivo investigar a associação entre os níveis do fator de crescimento semelhante à insulina tipo 1 (IGF-1) e a função cognitiva em idosos. Trata-se de uma revisão integrativa da literatura, realizada por meio de buscas nas bases de dados PubMed, Scopus, Embase e LILACS. Inicialmente, foram identificados 2.559 registros e, após a aplicação dos critérios de elegibilidade, 12 estudos foram incluídos na síntese final, totalizando 7.483 idosos participantes. Entre os instrumentos utilizados para avaliação da função cognitiva, destacou-se o Mini-Exame do Estado Mental (MMSE), empregado em 58,33% dos estudos, sendo o teste mais frequentemente utilizado. De modo geral, os resultados evidenciaram associação entre os níveis de IGF-1 e a função cognitiva, indicando que indivíduos com níveis mais elevados desse hormônio apresentaram melhor desempenho nos testes cognitivos. Assim, conclui-se que os níveis de IGF-1 estão associados à cognição em idosos, sugerindo que concentrações mais elevadas desse fator podem contribuir para a manutenção da função cognitiva, enquanto níveis reduzidos podem estar relacionados ao declínio cognitivo durante o envelhecimento.
Resumo (en)
This study aimed to investigate the association between the levels of insulin-like growth factor 1 (IGF-1) and cognitive function in older adults. This is an integrative literature review conducted through searches in the PubMed, Scopus, Embase, and LILACS databases. Initially, 2,559 records were identified and, after applying the eligibility criteria, 12 studies were included in the final synthesis, totaling 7,483 older adult participants. Among the instruments used to assess cognitive function, the Mini-Mental State Examination (MMSE) stood out, being used in 58.33% of the studies, making it the most frequently applied test. Overall, the results showed an association between IGF-1 levels and cognitive function, indicating that individuals with higher levels of this hormone presented better performance in cognitive tests. Thus, it is concluded that IGF-1 levels are associated with cognition in older adults, suggesting that higher concentrations of this factor may contribute to the maintenance of cognitive function, whereas lower levels may be related to cognitive decline during aging.
Resumo (es)
Este estudio tuvo como objetivo investigar la asociación entre los niveles del factor de crecimiento similar a la insulina tipo 1 (IGF-1) y la función cognitiva en personas mayores. Se trata de una revisión integrativa de la literatura, realizada mediante búsquedas en las bases de datos PubMed, Scopus, Embase y LILACS. Inicialmente, se identificaron 2.559 registros y, tras la aplicación de los criterios de elegibilidad, 12 estudios fueron incluidos en la síntesis final, totalizando 7.483 adultos mayores participantes. Entre los instrumentos utilizados para evaluar la función cognitiva, destacó el Mini-Examen del Estado Mental (MMSE), empleado en 58,33% de los estudios, siendo la prueba más utilizada. En general, los resultados evidenciaron una asociación entre los niveles de IGF-1 y la función cognitiva, indicando que los individuos con niveles más elevados de esta hormona presentaron mejor desempeño en las pruebas cognitivas. Así, se concluye que los niveles de IGF-1 están asociados con la cognición en adultos mayores, lo que sugiere que concentraciones más elevadas de este factor pueden contribuir al mantenimiento de la función cognitiva, mientras que niveles reducidos pueden estar relacionados con el deterioro cognitivo durante el envejecimiento.
Referências
Al-Delaimy, W. K., von Muhlen, D., & Barrett-Connor, E. (2009). Insulin-like growth factor-1, insulin-like growth factor binding protein-1, and cognitive function in older men and women. Journal of the American Geriatrics Society, 57(8), 1441–1446. https://doi.org/10.1111/j.1532-5415.2009.02343.x
Almeida, O. P., Hankey, G. J., Yeap, B. B., Chubb, S. A. P., Golledge, J., & Flicker, L. (2018). Risk of prevalent and incident dementia associated with insulin-like growth factor and insulin-like growth factor-binding protein 3. Molecular Psychiatry, 23(8), 1825–1829. https://doi.org/10.1038/mp.2017.152
Aleman, A., de Vries, W. R., de Haan, E. H. F., Verhaar, H. J. J., Samson, M. M., & Koppeschaar, H. P. F. (2000). Age-sensitive cognitive function, growth hormone and insulin-like growth factor 1 plasma levels in healthy older men. Neuropsychobiology, 41(2), 73–78. https://doi.org/10.1159/000026636
Aleman, A., Verhaar, H. J. J., de Haan, E. H. F., de Vries, W. R., Samson, M. M., Drent, M. L., & Koppeschaar, H. P. F. (1999). Insulin-like growth factor-I and cognitive function in healthy older men. The Journal of Clinical Endocrinology and Metabolism, 84(2), 471–475. https://doi.org/10.1210/jcem.84.2.5455
Arwert, L. I., Veltman, D. J., Deijen, J. B., Lammertsma, A. A., Jonker, C., & Drent, M. L. (2005). Memory performance and the growth hormone/insulin-like growth factor axis in elderly: A positron emission tomography study. Neuroendocrinology, 81(1), 31–40. https://doi.org/10.1159/000084872
Ashpole, N. M., Sanders, J. E., Hodges, E. L., Yan, H., & Sonntag, W. E. (2015). Growth hormone, insulin-like growth factor-1 and the aging brain. Experimental Gerontology, 68, 76–81. https://doi.org/10.1016/j.exger.2014.10.002
Bellar, D., Glickman, E. L., Juvancic-Heltzel, J., & Gunstad, J. (2011). Serum insulin-like growth factor-1 is associated with working memory, executive function, and selective attention in a sample of healthy, fit older adults. Neuroscience, 178, 133–137. https://doi.org/10.1016/j.neuroscience.2010.12.023
Calvo, D., Gunstad, J., Miller, L. A., Glickman, E., & Spitznagel, M. B. (2013). Higher serum insulin-like growth factor-1 is associated with better cognitive performance in persons with mild cognitive impairment. Psychogeriatrics, 13(3), 170–174. https://doi.org/10.1111/psyg.12023
Dik, M. G., Pluijm, S. M. F., Jonker, C., Deeg, D. J. H., Lomecky, M. Z., & Lips, P. (2003). Insulin-like growth factor I (IGF-I) and cognitive decline in older persons. Neurobiology of Aging, 24(4), 573–581. https://doi.org/10.1016/s0197-4580(02)00136-7
Doi, T., Makizako, H., Tsutsumimoto, K., Hotta, R., Nakakubo, S., Makino, K., Suzuki, T., & Shimada, H. (2018). Association between insulin-like growth factor-1 and frailty among older adults. The Journal of Nutrition, Health & Aging, 22(1), 68–72. https://doi.org/10.1007/s12603-017-0916-1
Doi, T., Shimada, H., Makizako, H., Tsutsumimoto, K., Hotta, R., Nakakubo, S., & Suzuki, T. (2015). Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed. Neurobiology of Aging, 36(2), 942–947. https://doi.org/10.1016/j.neurobiolaging.2014.10.035
Frater, J., Lie, D., Bartlett, P., & McGrath, J. J. (2018). Insulin-like growth factor 1 (IGF-1) as a marker of cognitive decline in normal ageing: A review. Ageing Research Reviews, 42, 14–27. https://doi.org/10.1016/j.arr.2017.12.002
Huang, X., Zhao, X., Li, B., Cai, Y., Zhang, S., Yu, F., & Wan, Q. (2021). Biomarkers for evaluating the effects of exercise interventions in patients with MCI or dementia: A systematic review and meta-analysis. Experimental Gerontology, 151, 111424. https://doi.org/10.1016/j.exger.2021.111424
Kalmijn, S., Janssen, J. A. M. J. L., Pols, H. A. P., Lamberts, S. W. J., & Breteler, M. M. B. (2000). A prospective study on circulating insulin-like growth factor I (IGF-I), IGF-binding proteins, and cognitive function in the elderly. The Journal of Clinical Endocrinology and Metabolism, 85(12), 4551–4555. https://doi.org/10.1210/jcem.85.12.7033
Kang, D., Waldvogel, H. J., Wang, A., Fan, D., Faull, R. L. M., Curtis, M. A., Shorten, P. R., & Guan, J. (2021). The autocrine regulation of insulin-like growth factor-1 in human brain of Alzheimer’s disease. Psychoneuroendocrinology, 127, 105191. https://doi.org/10.1016/j.psyneuen.2021.105191
Kang, J., Luo, W., Zhang, C., Ren, Y., Cao, L., Wu, J., & Li, H. (2021). Positive association between serum insulin-like growth factor-1 and cognition in patients with cerebral small vessel disease. Journal of Stroke and Cerebrovascular Diseases, 30(7), 105790. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105790
King, M., Kelly, L. P., Wallack, E. M., Hasan, S. M. M., Kirkland, M. C., Curtis, M. E., & Ploughman, M. (2019). Serum levels of insulin-like growth factor-1 and brain-derived neurotrophic factor as potential recovery biomarkers in stroke. Neurological Research, 41(4), 354–363. https://doi.org/10.1080/01616412.2018.1564451
Landi, F., Capoluongo, E., Russo, A., Onder, G., Cesari, M., Lulli, P., Minucci, A., Pahor, M., Zuppi, C., & Bernabei, R. (2007). Free insulin-like growth factor-I and cognitive function in older persons living in community. Growth Hormone & IGF Research, 17(1), 58–66. https://doi.org/10.1016/j.ghir.2006.11.001
Li, D.-J., Tseng, P.-T., Stubbs, B., Chen, T.-Y., Lin, P.-Y., Chen, S.-L., Thompson, T., Adamis, D., & Chu, C.-S. (2018). Low peripheral levels of insulin growth factor-1 are associated with high incidence of delirium among elderly patients: A systematic review and meta-analysis. Archives of Gerontology and Geriatrics, 77, 13–18. https://doi.org/10.1016/j.archger.2018.03.011
Lin, F., Suhr, J., Diebold, S., & Heffner, K. L. (2014). Associations between depressive symptoms and memory deficits vary as a function of insulin-like growth factor (IGF-1) levels in healthy older adults. Psychoneuroendocrinology, 42, 118–123. https://doi.org/10.1016/j.psyneuen.2014.01.006
Maass, A., Düzel, S., Brigadski, T., Goerke, M., Becke, A., Sobieray, U., & Düzel, E. (2016). Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. NeuroImage, 131, 142–154. https://doi.org/10.1016/j.neuroimage.2015.10.084
Mogic, L., Rutter, E. C., Tyas, S. L., Maxwell, C. J., O’Connell, M. E., & Oremus, M. (2023). Functional social support and cognitive function in middle- and older-aged adults: A systematic review of cross-sectional and cohort studies. Systematic Reviews, 12(1), Article 51. https://doi.org/10.1186/s13643-023-02251-z
Okereke, O. I., Kang, J. H., Ma, J., Hankinson, S. E., Pollak, M. N., & Grodstein, F. (2007). Plasma IGF-I levels and cognitive performance in older women. Neurobiology of Aging, 28(1), 135–142. https://doi.org/10.1016/j.neurobiolaging.2005.10.012
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan—A web and mobile app for systematic reviews. Systematic Reviews, 5(1), Article 210. https://doi.org/10.1186/s13643-016-0384-4
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., et al. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71
Paula, M. da S., Gomes, N. D., & Dantas, E. H. M. (2024). Resistance training, cognitive function and the elderly: An integrative review. Revista de Pesquisa Cuidado é Fundamental Online, 16, e13410. https://doi.org/10.9789/2175-5361.rpcfo.v16.13410
Paulsen, A. J., Schubert, C. R., Pinto, A., Carlsson, C. M., Chappell, R. J., Fischer, M. E., & Cruickshanks, K. J. (2020). Neuroprotective biomarkers and cognitive function in a long-term prospective population-based study of aging US adults. Alzheimer Disease and Associated Disorders, 34(1), 31–39. https://doi.org/10.1097/wad.0000000000000341
Picillo, M., Pivonello, R., Santangelo, G., Pivonello, C., Savastano, R., Auriemma, R., Amboni, M., Scannapieco, S., Pierro, A., Colao, A., Barone, P., & Pellecchia, M. T. (2017). Serum IGF-1 is associated with cognitive functions in early, drug-naïve Parkinson’s disease. PLOS ONE, 12(10), e0186508. https://doi.org/10.1371/journal.pone.0186508
Rollero, A., Murialdo, G., Fonzi, S., Garrone, S., Gianelli, M. V., Gazzerro, E., Barreca, A., & Polleri, A. (1998). Relationship between cognitive function, growth hormone and insulin-like growth factor I plasma levels in aged subjects. Neuropsychobiology, 38(2), 73–79. https://doi.org/10.1159/000026520
Salem, L., Saleh, N., Désaméricq, G., Youssov, K., Dolbeau, G., Cleret, L., & Maison, P. (2016). Insulin-like growth factor-1 but not insulin predicts cognitive decline in Huntington’s disease. PLOS ONE, 11(9), e0162890. https://doi.org/10.1371/journal.pone.0162890
Shi, X., Zheng, J., Ma, J., Li, D., Gu, Q., Chen, S., & Li, M. (2023). Correlation between serum IGF-1 and EGF levels and neuropsychiatric and cognitive symptoms in Parkinson’s disease patients. Neurological Sciences, 44(3), 881–887. https://doi.org/10.1007/s10072-022-06490-1
Stein, A. M., da Silva, T. M. V., Coelho, F. G. M., Rueda, A. V., Camarini, R., & Galduróz, R. F. S. (2021). Acute exercise increases circulating IGF-1 in Alzheimer’s disease patients, but not in older adults without dementia. Behavioural Brain Research, 396, 112903. https://doi.org/10.1016/j.bbr.2020.112903
Tumati, S., Burger, H., Martens, S., van der Schouw, Y. T., & Aleman, A. (2016). Association between cognition and serum insulin-like growth factor-1 in middle-aged and older men: An 8-year follow-up study. PLOS ONE, 11(4), e0154450. https://doi.org/10.1371/journal.pone.0154450
Wennberg, A. M. V., Hagen, C. E., Machulda, M. M., Hollman, J. H., Roberts, R. O., Knopman, D. S., & Mielke, M. M. (2018). The association between peripheral total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 and functional and cognitive outcomes in the Mayo Clinic Study of Aging. Neurobiology of Aging, 66, 68–74. https://doi.org/10.1016/j.neurobiolaging.2017.11.017
Whittemore, R., & Knafl, K. (2005). The integrative review: Updated methodology. Journal of Advanced Nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x
Xu, L.-Z., Li, F.-Y., Li, B.-Q., Cao, S.-M., Li, Y., Xu, J., & Jia, J.-P. (2021). Decreased levels of insulin-like growth factor-1 are associated with Alzheimer’s disease: A meta-analysis. Journal of Alzheimer’s Disease, 82(3), 1357–1367. https://doi.org/10.3233/JAD-210516
Como Citar
Não houve disponibilização de dados dessa pesquisa de forma pública.
Licença
Copyright (c) 2026 Marckson da Silva Paula, Jani Cleria Pereira Bezerra, Neilson Duarte Gomes, Nilber Soares Ramos, Carlos Eduardo de Souza Pinto, Rodrigo Gomes de Souza Vale, Estélio Henrique Martin Dantas
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Os conteúdos da Revista de Investigación Cuerpo, Cultura y Movimiento são publicados sob a licença Creative Commons Creative Commons Atribución-NoComercial-CompartirIgual 4.0 Internacional (CC BY-NC-SA 4.0)
ACEITAÇÃO DAS CONDIÇÕES PELOS AUTORES
O envio do artigo implica a aceitação das condições expressas neste documento.
