Associação entre cognição e fator de crescimento semelhante à insulina I: revisão integrativa
Association between cognition and insulin-like growth factor I: an integrative review
Asociación entre cognición y factor de crecimiento similar a la insulina I: revisión integrativa
Resumen (es)
Este estudio tuvo como objetivo investigar la asociación entre los niveles del factor de crecimiento similar a la insulina tipo 1 (IGF-1) y la función cognitiva en personas mayores. Se trata de una revisión integrativa de la literatura, realizada mediante búsquedas en las bases de datos PubMed, Scopus, Embase y LILACS. Inicialmente, se identificaron 2.559 registros y, tras la aplicación de los criterios de elegibilidad, 12 estudios fueron incluidos en la síntesis final, totalizando 7.483 adultos mayores participantes. Entre los instrumentos utilizados para evaluar la función cognitiva, destacó el Mini-Examen del Estado Mental (MMSE), empleado en 58,33% de los estudios, siendo la prueba más utilizada. En general, los resultados evidenciaron una asociación entre los niveles de IGF-1 y la función cognitiva, indicando que los individuos con niveles más elevados de esta hormona presentaron mejor desempeño en las pruebas cognitivas. Así, se concluye que los niveles de IGF-1 están asociados con la cognición en adultos mayores, lo que sugiere que concentraciones más elevadas de este factor pueden contribuir al mantenimiento de la función cognitiva, mientras que niveles reducidos pueden estar relacionados con el deterioro cognitivo durante el envejecimiento.
Resumen (pt)
Este estudo teve como objetivo investigar a associação entre os níveis do fator de crescimento semelhante à insulina tipo 1 (IGF-1) e a função cognitiva em idosos. Trata-se de uma revisão integrativa da literatura, realizada por meio de buscas nas bases de dados PubMed, Scopus, Embase e LILACS. Inicialmente, foram identificados 2.559 registros e, após a aplicação dos critérios de elegibilidade, 12 estudos foram incluídos na síntese final, totalizando 7.483 idosos participantes. Entre os instrumentos utilizados para avaliação da função cognitiva, destacou-se o Mini-Exame do Estado Mental (MMSE), empregado em 58,33% dos estudos, sendo o teste mais frequentemente utilizado. De modo geral, os resultados evidenciaram associação entre os níveis de IGF-1 e a função cognitiva, indicando que indivíduos com níveis mais elevados desse hormônio apresentaram melhor desempenho nos testes cognitivos. Assim, conclui-se que os níveis de IGF-1 estão associados à cognição em idosos, sugerindo que concentrações mais elevadas desse fator podem contribuir para a manutenção da função cognitiva, enquanto níveis reduzidos podem estar relacionados ao declínio cognitivo durante o envelhecimento.
Resumen (en)
This study aimed to investigate the association between the levels of insulin-like growth factor 1 (IGF-1) and cognitive function in older adults. This is an integrative literature review conducted through searches in the PubMed, Scopus, Embase, and LILACS databases. Initially, 2,559 records were identified and, after applying the eligibility criteria, 12 studies were included in the final synthesis, totaling 7,483 older adult participants. Among the instruments used to assess cognitive function, the Mini-Mental State Examination (MMSE) stood out, being used in 58.33% of the studies, making it the most frequently applied test. Overall, the results showed an association between IGF-1 levels and cognitive function, indicating that individuals with higher levels of this hormone presented better performance in cognitive tests. Thus, it is concluded that IGF-1 levels are associated with cognition in older adults, suggesting that higher concentrations of this factor may contribute to the maintenance of cognitive function, whereas lower levels may be related to cognitive decline during aging.
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Derechos de autor 2026 Marckson da Silva Paula, Jani Cleria Pereira Bezerra, Neilson Duarte Gomes, Nilber Soares Ramos, Carlos Eduardo de Souza Pinto, Rodrigo Gomes de Souza Vale, Estélio Henrique Martin Dantas
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